General anaesth Individualised based on patient's response.
Adult Manually Controlled Infusion (MCI) Induction of anaesth: Infusion rate of 0.5-1 mcg/kg/min, w/ or w/o bolus inj of 1 mcg/kg given over not <30 sec. Maintenance of anaesth in ventilated patients: 0.5-1 mcg/kg bolus inj; infusion starting rate w/ nitrous oxide: 0.4 mcg/kg/min (range: 0.1-2); w/ isoflurane: 0.25 mcg/kg/min (range: 0.05-2); w/ Propofol: 0.25 mcg/kg/min (range: 0.05-2). Supplemental analgesia in spontaneously breathing anaesthetized patients: Starting infusion rate of 0.04 mcg/kg/min.
Target-Controlled Infusion (TCI) Induction of anaesth & surgery: 3-8 ng/mL target blood remifentanil conc, titrated to individual patient response. Stimulating surgical procedures: Up to 15 ng/mL target blood remifentanil conc. ASA III/IV patients: 1.5-4 ng/mL, titrated to response.
Childn 1-12 yr Maintenance of anaesth: 1 mcg/kg bolus inj; continuous infusion starting rate: 0.25 mcg/kg/min; maintenance rate w/ halothane: 0.05-1.3 mcg/kg/min; w/ sevoflurane: 0.05-0.9 mcg/kg/min; w/ isoflurane: 0.06-0.9 mcg/kg/min.
Cardiac anaesth MCI Intubation: Continuous infusion rate of 1 mcg/kg/min. Maintenance of anaesth: 0.5-1 mcg/kg bolus inj. Starting infusion rate of 1 mcg/kg/min; typical infusion rates: 0.003-4 mcg/kg/min (w/ isoflurane); 0.01-4.3 mcg/kg/min (w/ Propofol). Continuation of post-op analgesia, prior to extubation: Starting infusion rate of 1 mcg/kg/min; typical infusion rates 0-1 mcg/kg/min.
Use in intensive care Adult Continuous infusion starting rate: 0.1-0.15 mcg/kg/min. Range: 0.006-0.74 mcg/kg/min.